Code | CSB-EP015511RA |
MSDS | |
Size | US$306 |
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This Recombinant Rat Ncam1 protein was made through genetic engineering. By putting the Ncam1 gene into the genetic material of E.coli cell, the E.coli could be used as factories or producers to make the desired Ncam1 protein for research uses. The expression region of this protein is at 20-721aa. N-terminal 10xHis tag and C-terminal Myc tag was used in the expression process. The purity is 90%+ determined by SDS-PAGE.
NCAM1 belongs to the immunoglobulin superfamily of adhesion molecules. 5 A wide range of alternatively spliced NCAM1 messenger RNAs (mRNAs) has been described to date, but only the 120-, 140-, and 180- kDa isoforms are commonly expressed. NCAM1 plays an important role in the regulation of neurogenesis, neurite outgrowth, proliferation, and cell migration, however, its function in hematopoiesis, including NK cells, is poorly understood. NCAM1 signaling is mediated either by homophilic or heterophilic interactions with fibroblast growth factor receptor (FGFR), L1-CAM, N-cadherin and other components of the extracellular matrix. Upon activation, NCAM1 triggers a variety of signaling cascades including FYN–focal adhesion kinase (FAK), MAPK, and phosphatidylinositol 3-kinase (PI3K) pathways. NCAM1 represents the major isoform expressed in cancer cells and has also been described in several tumor entities such as glioma, ovarian cancer, and small cell lung cancer. Functionally, NCAM1 expression is linked to disease progression.There are currently no reviews for this product.